AJT Paul I. Terasaki, PHD, 1929-2015.
- Cecka JM, Gjertson DW, Reed EF
- Paul I. Terasaki, PHD, 1929-2015. [JOURNAL ARTICLE]
- Am J Transplant 2016 Feb 5.
He created the microcytotoxicity test for HLA typing (which allowed the field of histocompatibility to advance on an international scale as it required only one microliter of the rare human alloantisera used to identify HLA antigens) and was a champion of HLA matching between kidney donors and recipients to improve transplant outcomes. But Paul was as interested in the human alloantibodies that defined HLA types as he was in their targets and realized that those antibodies could damage a transplanted kidney. He developed the lymphocyte crossmatch test in the mid-1960s that dramatically reduced the incidence of catastrophic hyperacute rejections and is still used in more sensitive forms today. By reversing the microcytotoxicity test, he made it possible to identify sensitized patients awaiting a transplant and to estimate their chances of finding a crossmatch compatible donor. This article is protected by copyright. All rights reserved.
http://www.unboundmedicine.com/medline/citation/26849675/Paul_I__Terasaki_PHD_1929_2015_
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Alberto Reino Buelvas
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