Metformin Use in Type 2 Diabetes Mellitus With CKD: Is It Time to Liberalize Dosing Recommendations?

American Journal of Kidney Diseases Metformin Use in Type 2 Diabetes Mellitus With CKD: Is It Time to Liberalize Dosing Recommendations?

Metformin is a very effective drug for type 2 diabetes mellitus (T2DM) with relatively few side effects1 and has other potential benefits, such as lowering of cardiovascular risk2,3 and possible lowering of cancer risk.4 However, there is concern that metformin may increase the risk of lactic acidosis in people with chronic kidney disease (CKD). Considering the number of people with CKD and T2DM,5,6 there are potentially millions of people who are not currently taking metformin who might benefit from this medication.


http://www.ajkd.org/article/S0272-6386(15)00611-3/abstract?rss=yes

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Alberto Reino Buelvas 

Médico Internista Nefrólogo