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Saturday, February 21, 2015

The Bionic Pancreas: Novel Perspectives on Insulin Replacement Therapies



Alberto Reino Buelvas 
Médico Internista Nefrólogo


Dramatic Improvement of Severe Cryptococcosis-Induced Immune Reconstitution Syndrome With Adalimumab in a Renal Transplant Recipient.

AJT Dramatic Improvement of Severe Cryptococcosis-Induced Immune Reconstitution Syndrome With Adalimumab in a Renal Transplant Recipient.

In solid organ transplant recipients, immune reconstitution inflammatory syndrome (IRIS) is a rare complication of cryptococcosis, which may require steroids in its most severe forms. Here, we report the case of a renal transplant recipient who developed severe cryptococcal meningitis-associated IRIS 1 week after immunosuppression reduction. High-dose steroids failed to improve the disease. Finally, a recombinant human monoclonal tumor necrosis factor-α (TNF-α) antagonist, adalimumab, was prescribed, and the patient rapidly experienced dramatic neurological improvement. No IRIS relapse occurred within 14 months following adalimumab discontinuation.



http://www.unboundmedicine.com/medline/citation/25611999/Dramatic_Improvement_of_Severe_Cryptococcosis_Induced_Immune_Reconstitution_Syndrome_With_Adalimumab_in_a_Renal_Transplant_Recipient_

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Alberto Reino Buelvas 
Médico Internista Nefrólogo


Tuesday, February 17, 2015

Consensus Conference on Best Practices in Live Kidney Donation: Recommendations to Optimize Education, Access, and Care.

KIDNEY TRANSPLANTATION NEWS Consensus Conference on Best Practices in Live Kidney Donation: Recommendations to Optimize Education, Access, and Care.

AJT Consensus Conference on Best Practices in Live Kidney Donation: Recommendations to Optimize Education, Access, and Care.

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation.



http://www.unboundmedicine.com/medline/citation/25648884/Consensus_Conference_on_Best_Practices_in_Live_Kidney_Donation:_Recommendations_to_Optimize_Education_Access_and_Care_

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Alberto Reino Buelvas 
Médico Internista Nefrólogo





http://feedproxy.google.com/~r/KidneyTransplantationNews/~3/-IFJf-uutHs/consensus-conference-on-best-practices.html

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Alberto Reino Buelvas

OPTN/SRTR 2013 Annual Data Report: Kidney.

KIDNEY TRANSPLANTATION NEWS OPTN/SRTR 2013 Annual Data Report: Kidney.

AJT OPTN/SRTR 2013 Annual Data Report: Kidney.

A new kidney allocation system, expected to be implemented in late 2014, will characterize donors on a percent scale (0%-100%) using the kidney donor profile index (KDPI). The 20% of deceased donor kidneys with the greatest expected posttransplant longevity will be allocated first to the 20% of candidates with the best expected posttransplant survival; kidneys that are not accepted will then be offered to remaining 80% of candidates. Waiting time will start at the time of maintenance dialysis initiation (even if before listing) or at the time of listing with an estimated glomerular filtration rate of 20 mL/min/1.73 m(2) or less. Under the current system, the number of candidates on the waiting list continues to increase, as each year more candidates are added than are removed. Median waiting times for adults increased from 3 years in 2003 to more than 4.5 years in 2009. Donation rates have not increased. Short-term outcomes continue to improve; death-censored graft survival at 90 days posttransplant was 97% or higher for deceased donor transplants and over 99% for living donor transplants. In 2013, 883 pediatric candidates were added to the waiting list; 65.8% of pediatric candidates on the list in 2013 underwent deceased donor transplant. Five-year graft survival was highest for living donor recipients aged younger than 11 years (89%) and lowest for deceased donor recipients aged 11 to 17 years (68%).



http://www.unboundmedicine.com/medline/citation/25626344/OPTN/SRTR_2013_Annual_Data_Report:_Kidney_

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Alberto Reino Buelvas 
Médico Internista Nefrólogo





http://feedproxy.google.com/~r/KidneyTransplantationNews/~3/BTd571GAyZU/optnsrtr-2013-annual-data-report-kidney.html

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Alberto Reino Buelvas

OPTN/SRTR 2013 Annual Data Report: Kidney.

AJT OPTN/SRTR 2013 Annual Data Report: Kidney.

A new kidney allocation system, expected to be implemented in late 2014, will characterize donors on a percent scale (0%-100%) using the kidney donor profile index (KDPI). The 20% of deceased donor kidneys with the greatest expected posttransplant longevity will be allocated first to the 20% of candidates with the best expected posttransplant survival; kidneys that are not accepted will then be offered to remaining 80% of candidates. Waiting time will start at the time of maintenance dialysis initiation (even if before listing) or at the time of listing with an estimated glomerular filtration rate of 20 mL/min/1.73 m(2) or less. Under the current system, the number of candidates on the waiting list continues to increase, as each year more candidates are added than are removed. Median waiting times for adults increased from 3 years in 2003 to more than 4.5 years in 2009. Donation rates have not increased. Short-term outcomes continue to improve; death-censored graft survival at 90 days posttransplant was 97% or higher for deceased donor transplants and over 99% for living donor transplants. In 2013, 883 pediatric candidates were added to the waiting list; 65.8% of pediatric candidates on the list in 2013 underwent deceased donor transplant. Five-year graft survival was highest for living donor recipients aged younger than 11 years (89%) and lowest for deceased donor recipients aged 11 to 17 years (68%).



http://www.unboundmedicine.com/medline/citation/25626344/OPTN/SRTR_2013_Annual_Data_Report:_Kidney_

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Alberto Reino Buelvas 
Médico Internista Nefrólogo


Consensus Conference on Best Practices in Live Kidney Donation: Recommendations to Optimize Education, Access, and Care.

AJT Consensus Conference on Best Practices in Live Kidney Donation: Recommendations to Optimize Education, Access, and Care.

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation.



http://www.unboundmedicine.com/medline/citation/25648884/Consensus_Conference_on_Best_Practices_in_Live_Kidney_Donation:_Recommendations_to_Optimize_Education_Access_and_Care_

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Alberto Reino Buelvas 
Médico Internista Nefrólogo